Ezra 4:4-5 –Then the people of the land weakened the hands of the people of Judah, and troubled them in building, And hired counsellors against them, to frustrate their purpose, all the days of Cyrus king of Persia, even until the reign of Darius king of Persia.

Would you like to find out what baffling, mean-spirited resistance feels like? Just start obediently to do God’s work.
The people of God, doing God’s work, have always faced resistance. From Noah, to Ezra, to Paul, down to this very day working against the grain has always been difficult.
Now to be honest, the Bible isn’t explicit about the opposition Noah faced. But look what it does say:

And God looked upon the earth, and, behold, it was corrupt; for all flesh had corrupted his way upon the earth. And God said unto Noah, The end of all flesh is come before me; for the earth is filled with violence through them; and, behold, I will destroy them with the earth. (Genesis 6:12-13)

I don’t think it’s much of a leap — and many have made it before me — to say that in a wicked world, when Noah started building the ark, he faced ridicule, abuse, and all kinds of active opposition!
When it comes to Ezra, the opposition is much more evident.
When Ezra and the people with him arrived from Babylon, started to rebuild the temple, first the enemies of Judah and Benjamin tried to infiltrate the project, then they tried to undermine morale. They hired counselors — influential men — to work against them through all the reign of King Cyrus. Finally, when Cyrus was succeeded by Ahasuerus (Xerxes), they go so far as to send a letter containing outright lies in a desperate attempt finally to close the the temple building down.
The opposition to Paul is easy to document too! Much of the Book of Acts documents his travails, and he himself gives an intimidating summary in a letter to the Corinthians:

Of the Jews five times received I forty stripes save one. Thrice was I beaten with rods, once was I stoned, thrice I suffered shipwreck, a night and a day I have been in the deep; In journeyings often, in perils of waters, in perils of robbers, in perils by mine own countrymen, in perils by the heathen, in perils in the city, in perils in the wilderness, in perils in the sea, in perils among false brethren; In weariness and painfulness, in watchings often, in hunger and thirst, in fastings often, in cold and nakedness. (2 Corinthians 11:24-27)

It’s easy to see the opposition. We should look at the outcomes, though.
Paul, in the face of all opposition,planted the Church across Asia Minor, Greece, and at the heart of the empire in Rome itself. No worldly opposition could defeat his heavenly project.
Noah, despite any opposition, and despite his own flawed character, “ … prepared an ark to the saving of his house … and became heir of the righteousness which is by faith.” (Hebrews 11:7)
Ezra triumphed. In fact in a wonderfully ironic justice, not only did Ahasuerus command that the temple be finished — but even instructed Ezra’s opponents to pay for it!
That’s the way of it. Take on God’s work and you will face opposition, sometimes where you least expect it, even from those whose support you might fairly expect. But if you persist, you will win through … Even if you don’t always see the results.